An Overview on Datura stramonium L. (Jimson weed): A Notable Psychoactive Drug Plant
DOI:
https://doi.org/10.47672/ajns.423Keywords:
Datura stramonium, Hallucination, Intoxication, Botany, Substance abuseAbstract
Purpose: People often make use of this notorious plant, Datura stramonium L. (Jimson weed) without rationale which subsequently leads to its abuse along the process. Thus, this paper seeks to compile detailed information regarding the toxicity and the safe usage of this plant in order to curtail its negative impact among individuals.
Methodology: A lot of literatures, reports, short communication etc. from print and electronic media were consulted during the course of preparation of the article.
Findings: The notorious weed, jimson weed (Datura stramonium L.) is a hallucinating plant with both poisonous and medicinal properties. The neurotoxicity of the plant is attributed to the presence of tropane alkaloids which contain a methylated nitrogen atom (N-CH3) that block neurotransmitters in the brain. Ethno-medicinally, the frequent recreational abuse of D. stramonium has resulted in toxic syndromes. D. stramonium, consume in the form of paste or solution to relieve the local pain may not have a deleterious effect; however, oral and systemic administration may lead to severe anticholinergic symptoms which include dizziness, hallucination, loss of consciousness, nausea, hypertension, agitation, aggressiveness, photophobia, blurred vision and possibly coma which may last for several hours or days depending on the quantity consumed.
Unique contribution to Theory, Practice and Policy: The present comprehensive review was able to, underscores the botany, phytochemistry, intoxication,and precautionary measures for the safe and sound usage of D. stramonium among individuals. Sequel to that, it deems imperative for individuals, especially adolescents, to be acquainted of the toxic nature and potential risks associated with the use of this plant.
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References
Abebe, W. (1986). A survey of prescriptions used in traditional medicine in Gondar region, North-West Ethiopia: general pharmaceutical practice. J. Ethnopharm. 18: 147-165.
Ajungla L, Patil PP, Barmukh RB, Nikam TD. Influence of biotic and abiotic elicitors on accumulation of hyoscyamine and scopolamine in root cultures of Datura metel L. Indian J Biotechnol. 2009; 8(3): 317-322.
Berkov S, Zayed R, Doncheva T. (2006) Alkaloid patterns in some varieties of Datura stramonium. Fitoterapia. 77(3): 179-182.
Binev R., Valchev I. and Nikolov J. (2006). Clinical and pathological studies of jimson weed (datura stramonium) poisoning in horses. Trakia Journal of Sciences, Vol. 4, No. 3, pp 56-63.
Bouzidi A, Mahdeb N, Kara N. (2011) Toxicity studies of alkaloids of seeds of Datura stramonium and synthesis alkaloids in male rats. J Med Plants Res. 5(15): 3421-3431.
Bruni In.A. (1999). Farmacognosia generale e applicata, Piccin Nuova Libraria. pp. 387–388
Chang, S. S., Wu, M. L., Deng, J. F., Lee,C. C., Chin, T. F. and Liao, S. J. (1999). Poisoning by Datura leaves used as edible wild vegetables. Vet. and Human Toxicol. 41:242-245.
Darias, V., Brovo, L., Barquin, E., Horrera, D.M. and Fraile, C. (1986). Contribution to the ethnopharmcological study of the Canary Islands. J.Ethnopharml. 18: 169-193.
Datasheet report for Datura stramonium. Invasive Species Compendium. www.cabi. org/isc. Accessed: September 14, 2015.
De Foe V. and Senatore F .(1993). Medicinal plants and phytotherapy in the Amal Fitan Cost, Salerno province Campania, Southern Italy. J.Ethnopharml. 39: 39-51..
Dessanges, J.F. (2001). A history of nebulization. J. Aerosol. Med. 14 (1): 65–71.
Devi M.R., Bawari M., Paul S.B. and Sharma G.D. (2011). Neurotoxic and Medicinal Properties of Datura stramonium L. – Review. Assam University Journal of Science & Technology: Biological and Environmental Sciences Vol. 7 Number I, 139-144.
Diker D, Markovitz D, Rothman M, Sendovski U. (2007) Coma as a presenting sign of Datura stramonium seed tea poisoning. Eur J Intern Med. 18(4): 336-338.
Dugan GM, Gumbmann MR, Friedman M. (1989) Toxicological evaluation of Jimson weed (Datura stramonium) seed. Food Chem Toxicol. 27(8): 501-510.
Ertekin, V., Selimoglu, M. A. and Altinkaynak, S. (2005). A combination of unusual presentations of Datura stramonium intoxication in a child: Rhabdomyolysis and fulminant hepatitius. J. of Emergency Med. 28: 227- 228.
Evans In.W.C. (1989): Trease and Evans pharmacognosy, Baillière Tindall. pp. 554–559.
Fornoni J, Núñez-Farfán J. (2000) Evolutionary ecology of Datura stramonium: genetic variation and costs for tolerance to defoliation. Evolution. 54(3): 789-797.
Friedman, M. and Levin, E. (1989). Composition of jimson weed (Datura stramonium) seeds. J. of Agri.and Food Chem..37: 998-1005.
Gaire BP, and Subedi L. (2013) A review on the pharmacological and toxicological aspects of Datura stramonium L. J Integr Med. 11(2): 73-79.
Guharov, S.R., Barajas, M. (1991) Intense stimulant effect: atropine intoxication from the ingestion and smoking of Jimson weed (Datura stramonium). Vet. Toxicol. 33: 588-589.
Hirschmann GS, De Arias AR. (1990) A survey of medicinal plants of minas gerais, Brazil. J Ethnopharmacol. 29(2): 159-172.
Jakabová S, Vincze L, Farkas A, Kilár F, Boros B, Felinger A. (2012) Determination of tropane alkaloids atropine and scopolamine by liquid chromatography-mass spectrometry in plant organs of Datura species. J Chromatogr A. 1232: 295-301.
Jimson Weed (Datura stramonium) Poisoning. Clinical Toxicology Review Dec 1995, Vol 18 (No 3). The Vaults of erowid. www.erowid.org. Accessed: September 14, 2015.
John, D. (1984). One hundred useful drugs of the Kani tribes of Trivandum forest divisions, Kerala, India. Inter. J. crude drug Res. 22:17-39.
Karadaş S, Selvi Y, Şahin M, Selvi F, Öncü R, Özgökçe F. (2011) Datura stramonium intoxication: report of a case with psychiatric symptoms. Düşünen Adam: J Psychiatry Neuro Sci. 24(2): 152-154.
Khalili Najafabadi M,Atyabi. (2004). Evaluation of analgesic effect of Datura stramonium seed extract in hot plate and formalin tested on male rats. I. J.of med.and Arom.Plants. 20 (3): 309-322.
Khare CP. (2007) Indian medicinal plants. Delhi: Rajkamal Electric Press. 203.
King, F.B. (1984). Plants, People, and Paleoecology. Illinois State Museum Scientific Papers, Vol. 20, Illinois State Museum, Springfield.
Kirtikar KR, Basu BD. (1999) Indian medicinal plants. 2nd ed. Volume III. Dehradun: International Book Distributors. 1783-1787.
Kurzbaum A, Simsolo C, Kvasha L, Blum A. (2001) Toxic delirium due to Datura stramonium. Isr Med Assoc J. 3(7): 538-539.
Luna-Cavazos M, Bye R. Phytogeographic analysis of the genus Datura (Solanaceae) in continental Mexico. Rev Mex Biodivers. 2011; 82: 977-988.
Manandhar NP. (1995). Inventory of some herbal drugs of Myagai district, Nepal. Econ. Bot. 49: 371 – 379.
Mann, John. (1992). Murder, Magic, and Medicine. Oxford University Press, Oxford.
Müller, J.L. (1998). Love potions and ointment of witches: historical aspects of nightshade alkaloids. Cli. Toxicol. 36: 617–627.
Naudé TW, Gerber R, Smith RJ, Botha CJ. (2005) Datura contamination of hay as the suspected cause of an extensive outbreak of impaction colic in horses. J S Afr Vet Assoc. 76(2): 107-112
Norton S. Toxic effects of plants. In: Klaassen CD. (2008) Caserett and Doull’s toxicology, the basic science of poisons. 7th ed. New York: McGraw Hill. 1110.
Oberndorfer S, Grisold W, Hinterholzer G, Rosner M. (2002) Coma with focal neurological signs caused by Datura stramonium intoxication in a young man. J Neurol Neurosurg Psychiatr. 73(4): 458-459.
Oshima.T, Sagara.K, Tong Y, Zhan.G.G and Chen.Y.(1989).Screening methods in Pharmacology, Academic Press, New York, 61, (1965). Chem Pharm Bull .37: 2456.
Radford AE, Ahles HE, and Bell CR. (1964). Manual of the Vascular Flora of the Carolinas. University of North Carolina Press, Chapel Hill.
Spina SP, Taddei A. (2007) Teenagers with Jimson weed (Datura stramonium) poisoning. CJEM. 9(6): 467-468.
Spring MA. (1989). Ethnopharmacologic analysis of medicinal plants used by Laotian Hmong refugees in Minnesota. J. Ethnopharmacol . 26: 65-91.
Strahil Berkov , Rawia Zayed and Tsvetelina Doncheva..(2006). Alkaloid patterns in some varieties of Datura stramonium . Fitoterapia.77 (3):179-182
Weaveri S.E.and Warwick, S.L. 1984. The Biology of Canadian Weeds. 64. Datura stramonium L. Canadian Journal of Plant Science. www.pubs.aic.ca. Accessed September 14, 2015.
Weed Circular No.12, Jimsonweed, Datura stramonium L. by Wilber L. Mountain. Pennsylvania Department of Agriculture Bureau of Plant Industry. Spring 1987/
Weitz, G .(2003). Love and death in Wagner’s Tristan und Isolde. An epic anticholinergic crisis, British Med.J. 327: 1469–1471.
Wiebe T. H., Sigurdson E. S. and, Katz L.Y. (2008). Angel’s Trumpet (Datura stramonium) poisoning and delirium in adolescents in Winnipeg, Manitoba: Summer 2006. Paediatr Child Health, Vol 13 No 3.
Zagari A (1992). Medicinal plants Vol. 3, 5th ed. Tehran University Publication, No. 1810/3, Tehran, Iran. pp. 889.
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